Work Your Legs, Strengthen Your Brain

Posted on July 23, 2018 by TriVita

For centuries the relationship between physical activity and brain health has been acknowledged, but new studies are beginning to demonstrate the significance of movement on neurogenesis.

Based on work with mice, a new study published in the journal Frontiers in Neuroscience highlights the intricate brain-muscle connection. The study involved restraining the hind legs of mice for 28 days. Their ability to move normally was preserved, and no stress indicators were observed. A comparison group was allowed unrestricted movement. Examination of the sub-ventricular zone revealed that neural stem cell activity decreased by 70% in the restrained group, alongside significant deterioration of specialized nerve cells.

What does this mean for you?

The research suggests that movement—especially weight-bearing activity—activates neurological signals that maintain cellular integrity and stimulate new cell growth.

“Neurological health is not a one-way street with the brain telling the muscles ‘lift,’ ‘walk,’ and so on,” said lead author Raffaella Adami of Italy’s Universita degli Studi di Milano. “We are meant to be active—to walk, run, crouch, and use our legs to lift.”

While animal research doesn’t always translate directly to human outcomes, this study underscores the importance of consistent movement in maintaining long-term health.

“Our study supports the notion that people unable to perform load-bearing exercise—such as bedridden patients or astronauts on extended missions—not only lose muscle mass, but also experience measurable shifts in body chemistry and nervous system function,” said Dr. Adami.

The findings reinforce one clear takeaway: movement of any kind is better than none. For those with limitations, brain-boosting strategies include nutrition, supplementation, and strengthening meaningful relationships.

Learn more about nine evidence-based actions you can take to improve your brain fitness.